CNS-CENTRAL & PERIPHERAL NERVOUS SYSTEM DISEASES
|
Indication |
Model |
Species |
|
Alzheimer's disease |
APP/PS1 Mice |
mice |
|
5XFAD Mice |
mice |
|
|
Parkinson's disease |
6-OHDA-induced PD |
rat |
|
MPTP-induced PD |
monkey |
|
|
Depression/Anxiety |
Forced swimming |
rat, mice |
|
Dangling tail |
mice |
|
|
Open field |
rat, mice |
|
|
Rlevated pluWs maze, EPM |
rat, mice |
|
|
m-CPP-induced anxiety-like symptoms |
rat |
|
|
Chronic unpredictable mild stress (CUMS) |
mice |
|
|
Learned helplessness |
rat, mice |
|
|
Epilepsy |
PTZ-induced acute and chronic attacks |
rat |
|
monkey |
||
|
Sleep/Sedation/Anesthesia Induction |
Loss of righting reflex, LORR |
rat, mice |
|
Spontaneous activity level |
rat, mice |
|
|
Sedation rating |
dog, swine, monkey |
|
|
EEG telemetry |
rat, mice |
|
|
monkey |
||
|
Pain |
Acute gouty arthritis |
rat, mice, UOX mice |
|
Adjuvant arthritis |
rat, mice |
|
|
CIA arthritis |
rat, mice |
|
|
monkey |
||
|
Carrageenan-induced plantar swelling |
rat |
|
|
Formalin causedkey pain |
mice |
|
|
Acetic acid writhing |
mice |
|
|
Nerve block |
rat |
|
|
Postoperative incision pain |
rat |
|
|
dog |
||
|
Chronic neuralgia (CCI, SNI, SNL) |
rat |
|
|
Diabetic nerve pain |
mice |
|
|
Cancer pain Chemotherapy pain |
mice |
|
|
rat |
||
|
Trigeminal neuralgia |
rat |
|
|
MIA osteoarthritis |
rat |
|
|
ACLT Osteoarthritis |
dog |
|
|
Stroke |
Permanent ischemic MCAO |
rat |
|
Ischemia-reperfusion MCAO |
rat |
|
|
monkey |
||
|
Spinal Cord Injury (SCI) |
Spinal cord hemisection |
rat, monkey |
|
Spinal cord blow injury |
rat, monkey |
|
|
Drug dependence |
Natural withdrawal |
rat, mice |
|
Urge withdrawal |
rat, mice |
|
|
Conditioned Place Preference, CPP |
rat |
|
|
Self-administration |
rat |
|
|
Drug identification |
rat |
|
|
Migraine |
Capsaicin-induced vasodilation model |
rat |
|
monkey |
||
|
Somatic neurotoxicity |
Polio, herpes, measles, mumps, rubella, etc. |
monkey |
